Nutramigen vs Alimentum: Which is Better for a Baby with Reflux?

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Nutramigen vs Alimentum go head to head in this debate over which formula tastes and works better for babies with reflux, colic, or allergies.

When it comes to Nutramigen vs Alimentum, one formula does not win out over the other. They both have several pros and cons, and finding the best choice will depend on your baby and their own unique tastes.

And in case you didn’t know, you can get them for much cheaper on Amazon when you “Subscribe and Save”!

Read on to check out our full review of both formulas, so you can make an informed decision about which to try first!

Image of the Enfamil Nutramigen with Enflora LGG infant Formula, Powder, 12.6 Ounce Can, Pack of 6

Image of the Similac Alimentum Hypoallergenic Infant Formula for Food Allergies and Colic, Baby Formula, Powder, 12.1 ounces (Pack Of 6)


Enfamil Nutramigen is a hypoallergenic baby formula made with iron. It is meant to be used for babies with allergies, colic, reflux, intolerances, and upset stomach caused by cows milk formula. Like any hypoallergenic formula, you can expect to pay a bit more for this than a standard can of infant formula. There are two versions available, powdered or ready to feed (which comes in bottles).

Specialty Formula

Nutramigen is not your everyday formula. It is specially made to help babies with high needs like allergies, colic and gas. The unique formulation includes nutrients found in breastmilk to help your baby have a healthy immune system and growth.

Image of the Enfamil Nutramigen with Enflora LGG Infant Formula, Powder, 19.8 Ounce Can


This formula is made by Enfamil, makers of some of the most popular formulas on the market. When you buy this product, you know you are getting a well-made formula by a known brand. You can feel safe knowing that your baby is in good hands with a formula that has been used and loved by other moms for many years.

Dairy Free

This formula is made without dairy. Dairy can cause gas and fussiness in many infants. Try not to worry if your baby does seem to react to dairy. They generally will outgrow that intolerance at about a year old. However, until that time, a dairy-free formula such as Nutramigen will definitely help ease their symptoms. Babies that have severe cow’s milk dairy allergy will also find relief with this formula.

Soy Free, Too

Soy is a very common allergen in young babies. This Enfamil formula completely avoids all soy products, making it safe for babies who have MSPI, or milk soy protein intolerance. By leaving soy out of their formula, even more infants can use Nutramigen.

Works Quickly

Nutramigen is proven to work pretty quickly for babies with colic and gas. Since no mama ever wants to see her baby in pain, it is a relief to know that most babies will show improvement within 48 hours of using this formula. When my baby had reflux all I wanted to do was to make the pain go away, as quickly as I could! Knowing that this formula is proven to help quickly is a major plus in my book.

Image of the Enfamil Nutramigen with Enflora LGG Infant Formula, Powder, 19.8 Ounce Can

Nutritionally Sound

The last thing you need to worry about when you have a baby that is fussy is whether or not they are getting the nutrients they need! Nutramigen offers a structure close to breastmilk. Both DHA and ARA are included in this formula to help with brain and eye development. Babies can stay on this formula all the way until 12 months old, and thrive. There is no need to supplement with any other formulas.

Image of the Enfamil Nutramigen with Enflora LGG Infant Formula, Powder, 19.8 Ounce Can

Power of Two

With this formula, proteins are broken down into smaller parts. That means they won’t irritate the gut and intestines like a traditional formula might. There is also an included probiotic, to promote healing and strength in the intestines.  All of these features help to reduce and manage colic, reflux, and gas.

Image of the Enfamil Nutramigen with Enflora LGG Infant Formula, Powder, 19.8 Ounce Can

Possible Drawbacks


Nutramigen is expensive. However, if we look at nutramigen vs alimentum, there isn’t much difference at all in cost. Although, compared to a traditional formula, you need to expect to pay more for each container of powder. There are often sales and coupons you can clip online, so make sure to look at that before you buy.

Editor’s Note: Buying formula in a grocery store is the most expensive way to do it. You can save a lot of money by purchasing your formula on Amazon and clicking the “Subscribe and Save” checkbox.

If your baby needs a special formula, you probably already know the cost is going to be high. By knowing this ahead of time you can try to figure out how to make it more affordable for your family. 


Like any other hypoallergenic formula, Nutramigen doesn’t have the best taste in the world. To you, it might smell a little funny or off. The good news is, your infant likely doesn’t know that this type of formula has a stronger taste. Most babies will take to this formula easily, but same may refuse due to taste and smell.

Nutramigen Features:

  • Hypoallergenic formula for birth to 12 months
  • Includes Iron
  • Manages colic, gas, upset stomach, and reflux
  • Complete nutrition for infants (no need to supplement with anything else)
  • Includes a probiotic


Similac Alimentum is another hypoallergenic formula for babies with allergies or colic. It is to be used in place of a traditional infant formula or breastmilk. Since babies with colic and allergies require different accommodations, this formula isn’t meant for all babies. Just like Nutramigen, there is both a powder and a ready to feed version of this formula.

Fast Acting

Like the Enfamil formula reviewed above, this Similac hypoallergenic formula is also proven to work quickly. In fact, one study showed it starts working within 24 hours of use. When your baby is crying in pain, you feel so helpless. I know this from experience! Being able to reduce their discomfort quickly is a major necessity when looking for a new formula.

Image of the Similac Alimentum Hypoallergenic Infant Formula for Food Allergies and Colic, Baby Formula, Powder, 12.1 ounces (Pack Of 6)

Popular Brand

Formulas by Similar are preferred in hospitals and by many doctors. You probably won’t be using this formula straight after birth. If your baby does have colic, reflux, or an allergy, it will take time to figure that out. However, Similac is an extremely well known and trusted brand. Having that kind of recommendation can go a long way when you need to choose a formula for your sensitive kiddo.

Image of the Similac Alimentum Hypoallergenic Infant Formula for Food Allergies and Colic, Baby Formula, Powder, 12.1 ounces (Pack Of 6)


While it may not be the most appetizing of words, but this formula is basically pre-digested. Just like the Nutramigen we reviewed earlier, it has broken down proteins. These smaller proteins are better absorbed by your baby’s immature digestive system, so there is less work on their end. Less work means less fussiness, spitting up, and gas. Babies with allergies won’t react to this hypoallergenic specialty formula!

Image of the Similac Alimentum Hypoallergenic Infant Formula for Food Allergies and Colic, Baby Formula, Powder, 12.1 ounces (Pack Of 6)

Available in Two Forms

You can buy Alimentum as either a powdered formula in a can, or a ready to feed formula in a bottle. Most babies will be fine with either version once they are used to this formula. However, some babies may need to stick to one or the other version. It will depend on how sensitive your own child is, and it may take a few tries to figure it out!

Possible Drawbacks


Looks familiar, right? Similar to the Nutramigen, Similac’s Alimentum is expensive for a formula. If you compare it to the cost of a regular formula you may experience some sticker shock. The cost may even be out of reach for some families. The cost of this formula is a serious drawback, but some infants need a hypoallergenic food, so there isn’t much choice.

Editor’s Note: This specialty formula is expensive, but you can save a lot of money by clicking the “Subscribe and Save” checkbox on Amazon.


Since this is predigested, it doesn’t have the same sweet taste that a regular formula will have. If your baby is used to a traditional formula or breastmilk, they may reject the taste and smell. If that happens, you can always try the other hypoallergenic formula as well. Luckily, the majority of babies acclimate to the taste of this formula, even though parents might take longer to get used to it!

Alimentum Features

  • Pre-digested hypoallergenic infant formula
  • Includes Iron
  • Ready to feed or powder formulas available
  • Helps to manage allergies, colic, gas, reflux, fussiness, and upset stomach
  • Complete nutrition from birth to age 12 months

Image of the Similac Alimentum Hypoallergenic Infant Formula for Food Allergies and Colic, Baby Formula, Powder, 12.1 ounces (Pack Of 6)

Enfamil vs Similac Brands

Enfamil has several other products that may be good alternatives, and so does Similac. In Enfamil vs Similac, we compare a range of formulas offered by these two big brands. Unfortunately, formulas are trial-and-error until you find the right one for your baby.

Bottom Line

If your baby has reflux, colic, gas, or allergies, you are probably desperately searching for a formula that will help control their symptoms. These ailments can be a source of pain and discomfort for infants, so of course you are doing everything you can to get it under control! There are several infant formulas on the market that have special versions for babies with reflux.

The real issue here is that if your baby needs a hypoallergenic formula, you don’t have a lot of choices. If you look at Nutramigen vs Alimentum, there is no right or wrong way to go. The prices are comparable. Both include iron and DHA. Both are easy to buy online, with no prescription needed.

If I had to choose, I would start with Nutramigen, only because it includes a probiotic. A probiotic can promote gut health and healing, which your baby likely needs if they have an allergy, colic, or reflux. Since babies may reject these formulas due to taste, I would move on to Alimentum if Nutramigen didn’t work out for my child. Both brands are well known and trustworthy. Both formulas promise to work quickly and efficiently. Overall, you can’t go wrong with Enfamil Nutramigen or Similar Alimentum if you have a high needs baby that requires a specialty formula!

Megan Schipsi
Megan is a parent, teacher, and writer from Phoenix, Arizona. When she isn't blogging, Megan can be found hiking the deserts with her child and two old chihuahuas, teaching at a co-op preschool, or working on her master's degree online.

5 thoughts on “Nutramigen vs Alimentum: Which is Better for a Baby with Reflux?”

  1. Nutramigen actually does contain soy, you stated it diid not. It’s one of the first ingredients on the label actually.

    Also, would like to say- I’ve used Alimentum on my son (now 6), and it worked great. My newborn now is still incredibly gassy on it.
    We will be trying Nutramigen starting tomorrow.

    And one last note to anyone reading this… if possible, start your child on powder! It’s less expensive and tastes differently to baby. Many friends swear the same is true, so try powder first so you’re not stuck in my boat of buying a quart of premodern formula per day!

    • Just FYI – Soy “oil” as is in Nutramigen is different than soy protein. Nutramigen still won’t affect babies with soy protein intolerances.

  2. Karen,
    How did the switch go for you newborn? I am in the same boat, my first child was fine on almintium but my second child who is 6 weeks old is very fussy and having lots of gas. I was also considering switching to nutgramium.

  3. The Nutramigen has worked wonders for us, and yes it does taste horrible. After a week of not seeing results and our baby refusing to eat we contacted our gastro about switching. They said we could try the Alimentum but would recommend waiting til after 2 weeks.
    Day 12 he finally started eating over 20oz again (previously 28-32 oz) and the projectile spit up ended. These formulas are like water so we went from size 2 nipples to preemies or 1s depending on the nipple.
    I’d recommend picking one and sticking with it for a couple of weeks.
    Unless I missed it the article should also mention the different sugars being used in the formulas. The Nut uses corn syrup and the Ali uses sucrose.

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